the effect of diazoxide on ultrastructural changes following ischemia-reperfusion injury of rat brain
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abstract
a b s t r a c t introduction: even today there is no effective drug therapy to prevent neuronal loss after brain stroke. in the present study we studied the effect of mitochondrial katp channel regulators on neuronal ultrastructure after ischemia reperfusion in the rat. materials & methods: rats temporarily subjected to four vessels occlusion for 15 minutes followed by 24 hours reperfusion with or without k-atp channel regulators. results: neuronal ultrastructure significantly improved in k-atp channel opener (diazoxide) treated ischemia-reperfusion group compared with control group. discussion: our results showed that dizoxide treatment after ischemia reperfusion leads to better preservation of cortical neurons in rat.
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full textThe Effect of Diazoxide on Ultrastructural Changes Following Ischemia-Reperfusion Injury of Rat Brain
Article info: Received: 25 February 2009 First Revision: 10 March 2009 Accepted: 30 April 2009
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Journal title:
basic and clinical neuroscienceجلد ۱، شماره ۳، صفحات ۱۷-۲۰
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